HCID 86750099, compound → HCID 23362243, compound

Participants

Reaction Steps

A solution of ethyl (E)-3-[4-[2-[N-(2-benzoxazolyl)-N-methylamino]ethoxy]phenyl]-2-fluoropropenoate (3.79 g) in ethanol (80 mL) was hydrogenated over 10% Palladium-charcoal (0.74 g) at room temperature and pressure for 3 hrs. The mixture was filtered, concentrated in vacuo and the residue chromatographed twice on silica gel, firstly with 10% ethyl acetate in dichloromethane and then with 25% ethyl acetate in hexane as eluents to afford a gum. Crystallisation from ethyl acetate-hexane afforded the title compound, mp 65°-7° C.

Provenance & Evidence