Hydrochloric Acid → HCID 23362237, compound

Participants

Reaction Steps

A solution of 5-[4-[2-[N-(2-benzoxazolyl)-N-methylamino]ethoxy]benzyl]-2,4-thiazolidinedione (Eur. Patent Appl., Publication No. 0306228) (1.0 g) in 10% aqueous sodium hydroxide solution (25 mL) was heated at reflux under a nitrogen atmosphere for 1.75 hrs. The mixture was cooled, acidified to pH3 with concentrated hydrochloric acid and extracted with ethyl acetate (300 mL). The organic solution was washed with brine (100 mL), dried (MgSO4) and evaporated. The residue was redissolved in boiling ethyl acetate, filtered and allowed to cool and crystallise to afford the title compound, mp 154°-6° C.

Provenance & Evidence