1-(Piperidin-4-yl)-1,3-diazinan-2-one → HCID 21839893, compound

Participants

Reaction Steps

3-(3,4-Dichlorophenyl)-3-(5-hydroxy-2-methyl-3-oxo-2,3-dihydro-1H-isoindol-1-yl)propionaldehyde (0.23 g) was coupled to 4-(2-oxoperhydropyrimidine-1-yl)piperidine (0.136 g) by a method similar to that described in Example 8. The reaction product was not purified by chromatography but converted to the corresponding hydrochloride salt as described in the Example 8 to afford the title compound (0.220 g); mp 200°-210° C; MS: m/z=531(M+1); NMR: 1.0 (s,3), 1.99 (s,1), 2.36 (m,2), 2.7 (m,2), 3.26 (s,3),4.65 (s,1), 5.94 (d,1, J=7.7), 7.18-7.41 (m,9), 7.54 (d,1, J=8.31), 7.77 (d, J=7.5). Analysis for C32H35Cl2N3O2.1.0 HCl.1.5 H2O: Calculated: C, 54.51; H, 6.09, N, 9.41; Found: C, 54.82; H, 5.78; N, 9.41.

Provenance & Evidence