1-(Piperidin-4-yl)-1,3-diazinan-2-one → HCID 21839987, compound

Participants

Reaction Steps

3-(3,4-Dichlorophenyl)-3-(5-bromo-2-methyl-3-oxo-2,3-dihydro-1H-isoindol-1-yl)propionaldehyde (0.325 g) was coupled to 4-(2-oxoperhydropyrimidine-1-yl)piperidine (0.139 g) by a method similar to that described in Example 8. The reaction product was not purified by chromatography but converted to the corresponding hydrochloride salt as described in the Example 8 to afford the title compound (0.34 g); mp 195°-205° C. (d); MS: m/z=595(M+); NMR(CD3SOCD3): 1.67-1.92 (m,5), 3.29 (s,3), 4.64 (m,2), 5.21 (s,1), 6.63 (d,1, J=7.6), 6.89 (s,1), 7.20 (d,1, J=8), 7.63-7.82 (m,3). Analysis for C27H31Cl2N4O2Br·0.75 H2O·1.0 HCl: Calculated C, 50.33; H, 5.24, N, 8.70; Found: C, 50.31; H, 5.33; N, 8.43.

Provenance & Evidence