1-(Piperidin-4-yl)-1,3-diazinan-2-one → HCID 21839891, compound

Participants

Reaction Steps

3-(3,4-Dichlorophenyl)-3-(5-aminocarbonyl-2-methyl-3-oxo-2,3-dihydro-1H-isoindol-1-yl)propionaldehyde (0.2 g) was coupled to 4-(2-oxoperhydropyrimidine-1-yl)piperidine (0.093 g) by a method similar to that described in Example 8. The reaction product was not purified by chromatography but converted to the corresponding hydrochloride salt as described in the Example 8 to afford the title compound (0.19 g); mp 240°-250° C. (d); MS: m/z=558(M+1); NMR: 2.60-2.77 (m,3), 3.29 (broad, 3), 4.67 (m, 1), 5.21 (s,1), 6.63 (m, 1), 6.85 (s,1), 7.19 (d, J=8, 1), 7.63-7.82 (m,3). Analysis for C27H31Cl2N4O2Br·1.0H2O·1.3HCl ·0.2C4H10O: Calculated: C, 54.16; H, 6.04, N, 10.96; Found: C, 54.21; H, 5.86; N, 10.74.

Provenance & Evidence