1-(Piperidin-4-yl)-1,3-diazinan-2-one → HCID 21839895, compound

Participants

Reaction Steps

3-(3,4-Dichlorophenyl)-3-(4-chloro-2-methyl-3-oxo-2,3-dihydro-1H-isoindol-1-yl)propionaldehyde (0.695 g) was coupled to 4-(2-oxoperhydropyrimidine-1-yl)piperidine (0.31 g) by a method similar to that described in Example 8. The reaction product was not purified by chromatography but converted to the hydrochloride salt to afford the title compound (0.220 g); mp 175°-185° C.; MS: m/z=549(M+1); NMR(CD3OD): 1.92 (m,4), 2.13 (m,2), 2.54 (m, 2), 3.29 (s,3), 3.66 (m,3), 4.37 (m, 1), 6.76 (dd,1, J=8.3, 21), 6.96 (d,1, J=21), 7.29 (d,1, J=8), 7.5 (d,1, J=8), 7.65 (t, 1, J=7.8), 7.83 (d,1, J=7.5). Analysis for C29H31Cl13N4O2 ·2.5 H2O·1.0 HCl: Calculated: C, 53.14; H, 5.69, N, 8.55; Found: C, 53.13; H, 5.67; N, 9.51.

Provenance & Evidence