1-(Piperidin-4-yl)-1,3-diazinan-2-one → HCID 21839944, compound

Participants

Reaction Steps

3-(3,4-Dichlorophenyl)-3-(4-trifluoromethyl-2-methyl-3-oxo-2,3-dihydro-1H-isoindol-1-yl)propionaldehyde (0.416 g) was coupled to 4-(2-oxoperhydropyrimidine-1-yl)piperidine (0.183 g) by a method similar to that described in Example 8. The reaction product was not purified by chromatography but converted to the hydrochloride salt to afford the title compound (0.34 g); mp 190°-205° C. (d); MS: m/z=583(M+1); NMR(CD3SOCD3): 1.66 (m,2), 2.11 (m,1), 3.05 (s,3), 4.37 (m,1), 4.96 (m,1), 6.31 (m, 1), 6.75 (m,1), 6.90 (s,1), 7.34 (m, 1), 7.82 (s,1), 8.22 (m, 1). Analysis for C28H31Cl2N4O2F3 ·1.0 H2O·1.0 HCl: Calculated: C, 52.71; H, 5.37, N, 8.78; Found: C, 52.48; H, 5.22; N, 8.46.

Provenance & Evidence