N-(4-Phenylpiperidin-4-yl)acetamide → HCID 21839969, compound

Participants

Reaction Steps

3-(3,4-Dichlorophenyl)-3-(6-hydroxy-2-methyl-3-oxo-2,3-dihydro-1H-isoindol-1-yl)propionaldehyde (1.5 g) was coupled to 4-acetamido-4-phenylpiperidine (0.7 g) by a method similar to that described in Example 8. The reaction product was purified by chromatography and converted to the corresponding hydrochloride salt as described in Example 8 to afford the title compound (1.26 g); mp 212°-225° C.; MS: m/z=566(m+1); NMR: 2.00 (s,3), 2.22(m,5), 2.5 (m,2), 2.7(m,2), 2.99(s,3), 3.54(m, 1), 4.54 (d,1, J=3.4), 5.81 (s,1), 6.6 (m,1), 6.7 (m, 1), 6.97 (m, 1), 7.11 (m,2), 7.31 (m,6), 7.50 (d,1, J=8).

Provenance & Evidence