4-(2-(Methylsulfinyl)phenyl)piperidine → 3-[1-(3,4-Dichlorophenyl)-3-[4-(2-methylsulfinylphenyl)-piperidino)propyl]-2-ethyl-2,3-dihydroisoindol-1-one hydrochloride

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Reaction Steps

3-(3,4-Dichlorophenyl)-3-(2-ethyl-3-oxo-2,3-dihydro-1H-isoindol-1-yl)propionaldehyde (0.24 g) and 4-(2-methylsulfinylphenyl)piperidine (0.224 g) were coupled using conditions similar to those described Example 1 to give the title compound (0.198 g); mp 150° C. (dec); MS: m/z=571(M+1); NMR (CD3OD): 1.3 (m,3), 2.0 (m, 6), 2.6 (m,1), 3.3 (m, 12), 5.05 (m,1), 7.28 (m,11). Analysis for C31H34Cl2N2O2A·1.0 HCl·0.9 H2O: Calculated: C, 59.83; H, 5.96; N, 74.50; Found: C, 59.55; H, 5.76; N, 4.89.

Provenance & Evidence