1-(Piperidin-4-yl)-1,3-diazinan-2-one → 3-[1-(3,4-Dichlorophenyl)-3-(4-(2-oxoperhydropyrimidin-1-yl)piperidino)propyl]-2-ethyl-2,3-dihydroisoindol-1-one hydrochloride

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Reaction Steps

A solution of 3-(3,4-dichlorophenyl)-3-(2-ethyl-3-oxo-2,3-dihydroisoindol-1-yl)propionaldehyde (0.36 g) was treated with 4-(2-oxoperhydropyrimidin-1-yl)piperidine (0.183 g) as described in Example 8. The resulting material was purified by chromatography and was transformed into the hydrochloride to afford the title compound (0.23 g); mp 165°-170° C.; MS: m/z=557(M+1); NMR(CD3OD): 2.3 (m, 7), 2.9 (m, 10), 3.45 (m, 1), 4.0 (m, 1), 4.3 (m,1), 5.0 (m, 1), 7.25 (m,7). Analysis for C28H34Cl2N4O2 ·1.0 HCl ·1.2 H2O: Calculated: C, 57.23; H, 6.41; N, 9.53; Found: C, 57.16; H, 6.21; N, 9.28.

Provenance & Evidence