4-(2-(Methylsulfinyl)phenyl)piperidine → 3-[1-(3,4-Dichlorophenyl)-3-(4-(2-methylsulfinylphenyl)piperidino)propyl]-2-propyl-2,3-dihydroisoindol-1-one hydrochloride

Participants

Reaction Steps

A solution of 3-(3,4-dichlorophenyl)-3-(2-propyl-3-oxo-2,3-dihydro-1H-isoindol-1-yl)propionaldehyde (0.235 g) was treated with 4-(2-methylsulfinylphenyl)piperidine (0.236 g) as described in Example 8. The resulting material was purified by chromatography and was transformed into the hydrochloride to afford the title compound (0.09 g); mp 78°-85° C. (dec); MS: m/z=583(M+1); NMR(CD3OD): 0.92 (m,3), 1.5-4.3 (m,21), 4.98-5.04 (m, 1), 7.27 (m,11). Analysis for C32H36Cl2N2O2S·1.0 HCl·0.5 H2O: Calculated: C, 61.09; H, 6.08; N, 4.45; Found: C, 60.78; H, 5.68; N, 4.67.

Provenance & Evidence