Cyanamide → {4-Amino-2-[4-(4-methyl-piperazin-1-yl)-phenylamino]-thiazol-5-yl}-(3-hydroxy-phenyl)-methanone

Participants

Role	Name	HCID	Charge
Reactant	Cyanamide	HCID 9864	—
Reactant	3-Hydroxyphenacyl bromide	HCID 6917206	—
Reactant	1-(4-Isothiocyanatophenyl)-4-cyclopropylmethylpiperazine	HCID 21958916	—
Product	{4-Amino-2-[4-(4-methyl-piperazin-1-yl)-phenylamino]-thiazol-5-yl}-(3-hydroxy-phenyl)-methanone	HCID 21958956	—

Reaction Steps

This compound was prepared from cyanamide, 1-(4-isothiocyanatophenyl)-4-cyclopropylmethylpiperazine (of Example 1) and 2-bromo-1-(3-hydroxyphenyl)ethanone (of Example 14N) following the procedure used in Example 24. Mass spectrum (ES) MH+=410.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US07094896B2
Source dataset	uspto-grants-2006_08
ORD ID	ord-25d1fdad70a740bb8250dd9d84aad07f
Source note	uspto-grants-2006_08