反应详情

To a suspension of 2-(6-aminopyrimidin-4-yloxy)ethanol (400 mg) in methanol (4 ml) is added dropwise a solution of bromine (437 mg) in methanol (2 ml). The mixture is evaporated to remove the solvent, and the residue is dissolved in ethyl acetate. The mixture is treated with saturated aqueous sodium hydrogen carbonate solution, and extracted with ethyl acetate/tetrahydrofuran. The organic layer is washed, dried, and evaporated to remove the solvent to give 2-(6-amino-5-bromopyrimidin-4-yloxy)ethanol (632 mg).

1. customThe mixture is evaporated
2. customto remove the solvent
3. dissolutionthe residue is dissolved in ethyl acetate
4. additionThe mixture is treated with saturated aqueous sodium hydrogen carbonate solution
5. extractionextracted with ethyl acetate/tetrahydrofuran
6. washThe organic layer is washed
7. customdried
8. customevaporated
9. customto remove the solvent