HuagongsheHuagongshe Chemistry Print Report · For research reference only
4,6-Dichloro-5-(4-methylphenyl)pyrimidine → 5-(4-Methylphenyl)-4,6-dichloro-2-phenylpyrimidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4,6-Dichloro-5-(4-methylphenyl)pyrimidine | HCID 21979554 | — |
| Reactant | HCID 178418453 | HCID 178418453 | — |
| Solvent | Diethyl Ether | HCID 3283 | — |
| Product | 5-(4-Methylphenyl)-4,6-dichloro-2-phenylpyrimidine | HCID 19689470 | — |
Reaction Steps
A solution of 5-(4-methylphenyl)-4,6-dichloropyrimidine in ether is cooled at -30° C., and thereto is added dropwise a 1.8M phenyl lithium/cyclohexane solution. The reaction mixture is treated in the same manner as in Reference Example 20-(1) to give 5-(4-methylphenyl)-4,6-dichloro-2-phenylpyrimidine as crystalline powder.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05589478 |
| Source dataset | uspto-grants-1996_12 |
| ORD ID | ord-f7683fce38a94024be8ecaec0a76c08e |
| Source note | uspto-grants-1996_12 |