N-({(5S)-3-[3-fluoro-4-(6-methoxypyridin-3-yl)phenyl]-2-oxo-1,3-oxazolidin-5-yl}methyl)acetamide → N-({(5S)-3-[3,5-difluoro-4-(6-methoxypyridin-3-yl)phenyl]-2-oxo-1,3-oxazolidin-5-yl}methyl)acetamide

Participants

Role	Name	HCID	Charge
Reactant	N-({(5S)-3-[3-fluoro-4-(6-methoxypyridin-3-yl)phenyl]-2-oxo-1,3-oxazolidin-5-yl}methyl)acetamide	HCID 10269812	—
Reactant	(S)-N-[[3-(4-iodo-3,5-difluorophenyl)-2-oxo-5-oxazolidinyl]methyl]acetamide	HCID 54435806	—
Product	N-({(5S)-3-[3,5-difluoro-4-(6-methoxypyridin-3-yl)phenyl]-2-oxo-1,3-oxazolidin-5-yl}methyl)acetamide	HCID 69557831	—

Reaction Steps

N-({(5S)-3-[3,5-difluoro-4-(6-methoxypyridin-3-yl)phenyl]-2-oxo-1,3-oxazolidin-5-yl}methyl)acetamide is prepared by the route described in Example 1 substituting N-{[(5S)-3-(3,5-difluoro-4-iodophenyl)-2-oxo-1,3-oxazolidin-5-yl]methyl}acetamide for N-({(5S)-3-[3-fluoro-4-(6-methoxypyridin-3-yl)phenyl]-2-oxo-1,3-oxazolidin-5-yl}methyl)acetamide. 1H-NMR (DMSO) δ: 8.25, 7.61, 7.30, 4.73, 4.10, 3.72, 3.49, 3.40, 2.30, 1.90, 1.83

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US07094900B2
Source dataset	uspto-grants-2006_08
ORD ID	ord-5f7428243e1e42a2ae90f190d4aceb30
Source note	uspto-grants-2006_08