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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1082903Generated: November 4, 2026

1-Methyl-1H-imidazole-4-carbonitrile → ethyl 4-(4-cyano-1-methyl-1H-imidazol-5-yl)-1-ethyl-1H-pyrrole-2-carboxylate

https://huagongshe.com/reaction/1082903

Reaction equation

Participants

RoleNameHCIDCharge
Reactant1-Methyl-1H-imidazole-4-carbonitrileHCID 2795115—
ReactantEthyl 4-bromo-1-ethyl-1H-pyrrole-2-carboxylateHCID 78918332—
ReagentPotassium TrimethylacetateHCID 23662159—
CatalystBis(3,5-bis(trifluoromethyl)phenyl)(3,6-dimethoxy-2',4',6'-tri(propan-2-yl)(1,1'-biphenyl)-2-yl)phosphaneHCID 44597232—
CatalystHCID 178455864HCID 178455864—
SolventDimethylacetamideHCID 31374—
Productethyl 4-(4-cyano-1-methyl-1H-imidazol-5-yl)-1-ethyl-1H-pyrrole-2-carboxylateHCID 11793778517.17%
Internal standard4,4'-Bis(1,1-dimethylethyl)-1,1'-biphenylHCID 74195—

Reaction Conditions

Temperature120 °C

Provenance & Evidence

DOI10.26434/chemrxiv
Source datasetPd-catalyzed C-H arylation of imidazole with aryl bromide
ORD IDord-f04348aa4f1647e5b2562fc7e4a4b5ce
Source notePd-catalyzed C-H arylation of imidazole with aryl bromide