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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1083669Generated: October 31, 2026

1-Bromo-2-fluorobenzene → HCID 178510011, compound

https://huagongshe.com/reaction/1083669

Reaction equation

Participants

RoleNameHCIDCharge
Reactant1-Bromo-2-fluorobenzeneHCID 61259—
ReactantBenzonitrile, p-imidazol-1-yl-HCID 135744—
ReagentPotassium TrimethylacetateHCID 23662159—
CatalystTris(2-methoxyphenyl)phosphineHCID 78464—
CatalystHCID 178455864HCID 178455864—
SolventDimethylacetamideHCID 31374—
ProductHCID 178510011HCID 1785100116.42%
Internal standard4,4'-Bis(1,1-dimethylethyl)-1,1'-biphenylHCID 74195—

Reaction Conditions

Temperature120 °C

Provenance & Evidence

DOI10.26434/chemrxiv
Source datasetPd-catalyzed C-H arylation of imidazole with aryl bromide
ORD IDord-c97c0eb4e4d44954acd3bd27c3e2317f
Source notePd-catalyzed C-H arylation of imidazole with aryl bromide