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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1083753Generated: October 31, 2026

2-Acetyl-5-bromothiophene → HCID 178466102, compound

https://huagongshe.com/reaction/1083753

Reaction equation

Participants

RoleNameHCIDCharge
Reactant2-Acetyl-5-bromothiopheneHCID 79335—
ReactantBenzonitrile, p-imidazol-1-yl-HCID 135744—
ReagentPotassium TrimethylacetateHCID 23662159—
Catalyst1,3,5,7-Tetramethyl-6-phenyl-2,4,8-trioxa-6-phosphaadamantaneHCID 53427790—
CatalystHCID 178455864HCID 178455864—
SolventDimethylacetamideHCID 31374—
ProductHCID 178466102HCID 17846610240.82%
Internal standard4,4'-Bis(1,1-dimethylethyl)-1,1'-biphenylHCID 74195—

Reaction Conditions

Temperature120 °C

Provenance & Evidence

DOI10.26434/chemrxiv
Source datasetPd-catalyzed C-H arylation of imidazole with aryl bromide
ORD IDord-033aa29e1ad04b23afd793e07bb736b9
Source notePd-catalyzed C-H arylation of imidazole with aryl bromide