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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1083813Generated: October 28, 2026

2-Acetyl-5-bromothiophene → HCID 178466099, compound

https://huagongshe.com/reaction/1083813

Reaction equation

Participants

RoleNameHCIDCharge
Reactant2-Acetyl-5-bromothiopheneHCID 79335—
Reactant1-(Difluoromethyl)-2-phenyl-1H-imidazoleHCID 53485766—
ReagentPotassium TrimethylacetateHCID 23662159—
CatalystTris(o-methoxyphenyl)phosphineHCID 78464—
CatalystHCID 178455864HCID 178455864—
SolventDimethylacetamideHCID 31374—
ProductHCID 178466099HCID 1784660992.83%
Internal standard4,4'-Bis(1,1-dimethylethyl)-1,1'-biphenylHCID 74195—

Reaction Conditions

Temperature120 °C

Provenance & Evidence

DOI10.26434/chemrxiv
Source datasetPd-catalyzed C-H arylation of imidazole with aryl bromide
ORD IDord-005a994ec4c34c48862502e7da851027
Source notePd-catalyzed C-H arylation of imidazole with aryl bromide