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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1083885Generated: November 1, 2026

1-Bromo-2-fluorobenzene → HCID 178505607, compound

https://huagongshe.com/reaction/1083885

Reaction equation

Participants

RoleNameHCIDCharge
Reactant1-Bromo-2-fluorobenzeneHCID 61259—
Reactant1-(Difluoromethyl)-2-phenyl-1H-imidazoleHCID 53485766—
ReagentPotassium TrimethylacetateHCID 23662159—
CatalystTris(2-methoxyphenyl)phosphineHCID 78464—
CatalystHCID 178455864HCID 178455864—
SolventDimethylacetamideHCID 31374—
ProductHCID 178505607HCID 17850560713.13%
Internal standard4,4'-Bis(1,1-dimethylethyl)-1,1'-biphenylHCID 74195—

Reaction Conditions

Temperature120 °C

Provenance & Evidence

DOI10.26434/chemrxiv
Source datasetPd-catalyzed C-H arylation of imidazole with aryl bromide
ORD IDord-ee46343e0e3849209a49f0afc9cb3fdf
Source notePd-catalyzed C-H arylation of imidazole with aryl bromide