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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1084013Generated: October 31, 2026

1-(Difluoromethyl)-2-phenyl-1H-imidazole → HCID 178468651, compound

https://huagongshe.com/reaction/1084013

Reaction equation

Participants

RoleNameHCIDCharge
Reactant1-(Difluoromethyl)-2-phenyl-1H-imidazoleHCID 53485766—
ReactantEthyl 4-bromo-1-ethyl-1H-pyrrole-2-carboxylateHCID 78918332—
ReagentPotassium TrimethylacetateHCID 23662159—
Catalyst2'-[(1,1-Dimethylethyl)phenylphosphino]-N2,N2,N6,N6-tetramethyl-[1,1'-biphenyl]-2,6-diamineHCID 121237783—
CatalystHCID 178455864HCID 178455864—
SolventDimethylacetamideHCID 31374—
ProductHCID 178468651HCID 17846865123.16%
Internal standard4,4'-Bis(1,1-dimethylethyl)-1,1'-biphenylHCID 74195—

Reaction Conditions

Temperature120 °C

Provenance & Evidence

DOI10.26434/chemrxiv
Source datasetPd-catalyzed C-H arylation of imidazole with aryl bromide
ORD IDord-a71dc830e2b347498bddc17aec2a17f6
Source notePd-catalyzed C-H arylation of imidazole with aryl bromide