Hydrochloric Acid → Dimethyl 5-methoxypyridine-2,4-dicarboxylate

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Reaction Steps

300 mg of dimethyl 5-bromopyridine-2,4-dicarboxylate (from Example 3) are dissolved in 5 ml of absolute methanol, and 120 mg of sodium methylate are added. After 60 hours under reflux, the mixture is poured onto ice and 2 ml of 2N HCl, rendered alkaline with NaHCO3 and extracted with 2 portions of CH2Cl2. After the extract has been dried over MgSO4, the solvent is evaporated. 175 mg of a white solid remain.

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