HCID 131716816, compound → HCID 18960803, compound

HRID 1084337Notes

Reaction equation

HRID 1084337 reaction equation
[OH:1][CH2:2][CH2:3][C:4]#[C:5][C:6]1[C:7]([C:16]([O:18][CH3:19])=[O:17])=[CH:8][C:9]([C:12]([O:14][CH3:15])=[O:13])=[N:10][CH:11]=1>CO.[Pd]>[OH:1][CH2:2][CH2:3][CH2:4][CH2:5][C:6]1[C:7]([C:16]([O:18][CH3:19])=[O:17])=[CH:8][C:9]([C:12]([O:14][CH3:15])=[O:13])=[N:10][CH:11]=1

Participants

4

Reactant 1

HCID 131716816HCID 131716816, compound

Product 1

HCID 18960803HCID 18960803, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

200 mg of dimethyl 5-(4-hydroxy-1-butinyl)-pyridine-2,4-dicarboxylate (from Example 7) are dissolved in 25 ml of methanol and, after addition of the palladium catalyst (10% strength on charcoal) are hydrogenated. The reaction has ended after 4 hours (thin layer control). The catalyst is filtered off and the solution is concentrated in vacuo. The colorless oil is chromatographed on silica gel.

Workup

  1. filtrationThe catalyst is filtered off
  2. concentrationthe solution is concentrated in vacuo
  3. customThe colorless oil is chromatographed on silica gel

Sources & evidence

ORD record
ord-04d06f7658624436997175466bb2e0f4
Source dataset
uspto-grants-1991_04
Patent number
US05004748

Reaction notes

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