HCID 131716817, compound → HCID 18960788, compound

HRID 1084338Notes

Reaction equation

HRID 1084338 reaction equation
[OH:1][CH:2]([CH2:19][CH3:20])[C:3]#[C:4][C:5]1[C:6]([C:15]([O:17][CH3:18])=[O:16])=[CH:7][C:8]([C:11]([O:13][CH3:14])=[O:12])=[N:9][CH:10]=1>CO.[Pd]>[OH:1][CH:2]([CH2:19][CH3:20])[CH2:3][CH2:4][C:5]1[C:6]([C:15]([O:17][CH3:18])=[O:16])=[CH:7][C:8]([C:11]([O:13][CH3:14])=[O:12])=[N:9][CH:10]=1

Participants

4

Reactant 1

HCID 131716817HCID 131716817, compound

Product 1

HCID 18960788HCID 18960788, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

317 mg of dimethyl 5-(3-hydroxy-1-pentinyl)-pyridine-2,4-dicarboxylate (Example 8) are dissolved in 25 ml of methanol and, after addition of the palladium catalyst (10% strength on charcoal) are hydrogenated. The reaction has ended after 4 hours (thin layer control). The catalyst is filtered off and the solution is concentrated in vacuo. The colorless oil is chromatographed on silica gel.

Workup

  1. filtrationThe catalyst is filtered off
  2. concentrationthe solution is concentrated in vacuo
  3. customThe colorless oil is chromatographed on silica gel

Sources & evidence

ORD record
ord-9d45dca97889498b9469618c76b88201
Source dataset
uspto-grants-1991_04
Patent number
US05004748

Reaction notes

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