HCID 131716818, compound → HCID 18960798, compound

HRID 1084339Notes

Reaction equation

HRID 1084339 reaction equation
[CH3:1][O:2][C:3]([CH2:5][CH2:6][C:7]#[C:8][C:9]1[C:10]([C:19]([O:21][CH3:22])=[O:20])=[CH:11][C:12]([C:15]([O:17][CH3:18])=[O:16])=[N:13][CH:14]=1)=[O:4]>CO.[Pd]>[CH3:1][O:2][C:3]([CH2:5][CH2:6][CH2:7][CH2:8][C:9]1[C:10]([C:19]([O:21][CH3:22])=[O:20])=[CH:11][C:12]([C:15]([O:17][CH3:18])=[O:16])=[N:13][CH:14]=1)=[O:4]

Participants

4

Reactant 1

HCID 131716818HCID 131716818, compound

Product 1

HCID 18960798HCID 18960798, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

305 mg of dimethyl 5-(4-methoxycarbonyl-1-butinyl)-pyridine-2,4-dicarboxylate (from Example 9) are dissolved in 30 ml of methanol and, after addition of the palladium catalyst (10% strength on charcoal) are hydrogenated. The reaction has ended after 4 hours (thin layer control). The catalyst is filtered off and the solution is evaporated in vacuo. The colorless oil is chromatographed on silica gel.

Workup

  1. filtrationThe catalyst is filtered off
  2. customthe solution is evaporated in vacuo
  3. customThe colorless oil is chromatographed on silica gel

Sources & evidence

ORD record
ord-56e3dfb8c325406aa2b7a36046aa1592
Source dataset
uspto-grants-1991_04
Patent number
US05004748

Reaction notes

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