HCID 131716819, compound → HCID 18960797, compound

HRID 1084340Notes

Reaction equation

HRID 1084340 reaction equation
[OH:1][CH2:2][C:3]#[C:4][C:5]1[C:6]([C:15]([O:17][CH3:18])=[O:16])=[CH:7][C:8]([C:11]([O:13][CH3:14])=[O:12])=[N:9][CH:10]=1>CO.[Pd]>[OH:1][CH2:2][CH2:3][CH2:4][C:5]1[C:6]([C:15]([O:17][CH3:18])=[O:16])=[CH:7][C:8]([C:11]([O:13][CH3:14])=[O:12])=[N:9][CH:10]=1

Participants

4

Reactant 1

HCID 131716819HCID 131716819, compound

Product 1

HCID 18960797HCID 18960797, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

655 mg of dimethyl 5-(3-hydroxy-1-propinyl)-pyridine-2,4-dicarboxylate (Example 10) are dissolved in 50 ml of methanol and, after addition of the palladium catalyst (10% strength on charcoal) are hydrogenated. The reaction has ended after 4 hours (thin layer control). The catalyst is filtered off and the solution is concentrated in vacuo. The colorless oil is chromatographed on silica gel.

Workup

  1. filtrationThe catalyst is filtered off
  2. concentrationthe solution is concentrated in vacuo
  3. customThe colorless oil is chromatographed on silica gel

Sources & evidence

ORD record
ord-cb7a6270fb814f1da4e9b4af99e05226
Source dataset
uspto-grants-1991_04
Patent number
US05004748

Reaction notes

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