HCID 131716821, compound → HCID 18960794, compound

HRID 1084341Notes

Reaction equation

HRID 1084341 reaction equation
[C:1]([CH2:3][CH2:4][CH2:5][C:6]#[C:7][C:8]1[C:9]([C:18]([O:20][CH3:21])=[O:19])=[CH:10][C:11]([C:14]([O:16][CH3:17])=[O:15])=[N:12][CH:13]=1)#[N:2]>CO.[Pd]>[C:1]([CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][C:8]1[C:9]([C:18]([O:20][CH3:21])=[O:19])=[CH:10][C:11]([C:14]([O:16][CH3:17])=[O:15])=[N:12][CH:13]=1)#[N:2]

Participants

4

Reactant 1

HCID 131716821HCID 131716821, compound

Product 1

HCID 18960794HCID 18960794, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

64 mg of dimethyl 5-(5-cyano-1-pentinyl)-pyridine-2,4-dicarboxylate (from Example 11) are dissolved in 25 ml of methanol and, after addition of the palladium catalyst (10% strength on charcoal), are hydrogenated. The reaction has ended after 4 hours (thin layer control). The catalyst is filtered off and the solution is concentrated in vacuo. The colorless oil is chromatographed on silica gel.

Workup

  1. filtrationThe catalyst is filtered off
  2. concentrationthe solution is concentrated in vacuo
  3. customThe colorless oil is chromatographed on silica gel

Sources & evidence

ORD record
ord-f37bab85a6914fec9e340ff4d077b885
Source dataset
uspto-grants-1991_04
Patent number
US05004748

Reaction notes

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