HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethanol → 8-Chloro-3-ethoxycarbonyl-7-fluoro-4-oxo-1-tert.-butyl-1,4-dihydro-benzo[b][1,8]naphthyridine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethanol | HCID 702 | — |
| Reactant | Tert-Butylamine | HCID 6385 | — |
| Reactant | Ethyl 2-(2,7-dichloro-6-fluoroquinoline-3-carbonyl)-3-dimethylaminoacrylate | HCID 54015905 | — |
| Solvent | Chloroform | HCID 6212 | — |
| Solvent | 1,8-Diazabicyclo(5.4.0)undec-7-ene | HCID 81184 | — |
| Product | 8-Chloro-3-ethoxycarbonyl-7-fluoro-4-oxo-1-tert.-butyl-1,4-dihydro-benzo[b][1,8]naphthyridine | HCID 14700553 | — |
Reaction Steps
The 8-chloro-3-ethoxycarbonyl-7-fluoro-4-oxo-1-tert.-butyl-1,4-dihydro-benzo[b][1,8]naphthyridine is prepared under the conditions of Example 17 but starting from 8.86 g of ethyl 2-(2,7-dichloro-6-fluoroquinoline-3-carbonyl)-3-dimethylaminoacrylate and 4.03 g of tert.-butylamine in 45 cm3 of trichloromethane and then in 4.53 g of DBU and 45 cm3 of ethanol 5 g of 8-chloro-3-ethoxycarbonyl-7-fluoro-4-oxo-1-tert.-butyl-1,4-dihydro-benzo[b][1,8]naphthyridine are obtained in the form of a yellow solid melting at 239° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05004745 |
| Source dataset | uspto-grants-1991_04 |
| ORD ID | ord-4f0b167fa6294b5fad1240ec14be8134 |
| Source note | uspto-grants-1991_04 |