1-Methylpiperazine → HCID 20063272, compound

Participants

Reaction Steps

The 3-ethoxycarbonyl-1-ethyl-7,9-difluoro-8-(4-methyl-1-piperazinyl)-4-oxo-1,4-dihydrobenzo[b][1,8]naphthyridine was prepared under the conditions of Example 3 but starting from 1.4 g of 3-ethoxycarbonyl-1-ethyl-7,8,9-trifluoro-4-oxo-1,4-dihydro-benzo[b][1,8]naphthyridine and 4 g of 1-methylpiperazine. 1.1 g of 3-ethoxycarbonyl-1-ethyl-7,9-difluoro-8-(4-methyl-1-piperazinyl)-4-oxo-1,4-dihydro-benzo[b][1,8]naphthyridine are obtained in the form of a yellow solid melting at 206° C.

Provenance & Evidence