HCID 67923404, compound → HCID 67923487, compound

Participants

Reaction Steps

(4R,6R)-(E)-4-hydroxy-6-[2-(4-(4-fluorophenyl)-2-isopropyl-1-oxo-1,2-dihydroisoquinolin-3-yl)ethen-1-yl]-3,4,5,6-tetrahydro-2H-pyran-2-one, m.p.207°-209° C. [α]D =-54° (CH2Cl2 at 29° C.) Found: C,71.0; H,5.47; N,3.37%. Required: C,71.2; H,5.74; N,3.32%. [NMR in CDCl3, 1.16 (1H,m), 1.68 (6H,d,J=8 Hz), 1.88 (1H,m), 2.45 (1H,dd,J=17 Hz and J=8 Hz), 2.58 (1H,d,J=5 Hz), 2.90 (1H,m), 4.22 (1H,m), 4.63 (2H,m), 5.50 (1H,dd,J=16 Hz and J=6 Hz), 6.41 (1H,dd,J=16 Hz), 6.98-7.25 (5H,m), 7.49 (2H,m), 8.42 (1H,m)];

Provenance & Evidence