HCID 20063346, compound → HCID 86744705, compound

Participants

Reaction Steps

A stirred solution of (E)-3-(2-methyl-1-oxo-4-phenyl-1,2-dihydroisoquinolin-3-yl)prop-2-en-1-ol (0.4 g) in dry diethyl ether (125 ml) under an atmosphere of nitrogen was treated with activated manganese dioxide (1.8 g). The mixture was stirred for 4 hours. The manganese dioxide was then filtered off and washed well with diethyl ether (4×100 ml) during 15 minutes. The combined ethereal solutions were evaporated, to give (E)-3-(2-methyl-1-oxo-4-phenyl-1,2-dihydroisoquinolin-3-yl)propenal (0.34 g) in the form of a yellow solid, m.p. 228° C.

Provenance & Evidence