Camptothecin → HCID 11024585, compound

Participants

Reaction Steps

Camptothecin (32.0 g, 0.092 mol.) obtained from Tainjain-SK&F Ltd., Tainjain, China, was combined with Pt0 [prepared by pre reduction of 8.0 g. amorphous PtO2 in 800 mL HOAc for 1.5 hour (h) under 1 atmosphere (atm.) H2 ] and HOAc (1.6 L). Reduction was carried out at 1 atm. H2 for 8.5 h. while vigorously stirring the mixture. At the end of this time, the theoretical amount of H2 had been absorbed (slightly more than 4.1 L) and the uptake of H2 had slowed considerably. The reaction was degassed with a stream of Ar for approximately 10 minutes (min.), and then filtered through a celite pad which was washed with HOAc (200 mL).

Provenance & Evidence