反应详情

温度

40 °C

3.5 g of (2-methyl-1-n-octylindol-3-yl)-(2-carboxyphenyl)ketone and 1.6 g of 6-dimethylamino-3-methylbenzofuran are suspended in 45 ml of acetic anhydride and heated to 40° C. After 2 hours the reaction product is poured onto ice, basified with concentrated sodium hydroxide solution and filtered off. The crude product is recrystallized from toluene/methanol to give 3.25 g of the 3-(6-dimethylamino-3-methyl-benzofuran-2-yl)-3-(2-methyl-1-n-octylindol-3-yl)phthalide compound of the formula ##STR28## having a melting point of 157°-158° C. The phthalide compound gives a green colour on acid-modified silica gel.

1. additionAfter 2 hours the reaction product is poured onto ice
2. filtrationfiltered off
3. customThe crude product is recrystallized from toluene/methanol