反应详情

A solution of 8.0 g of ethyl 2-(4-chlorophenyl)-3-nitropropyl-(diethoxymethyl)phosphinate in 70 ml of ethanol is added to 64 g of an 8% solution of ammonia in ethanol. To this are added 8 ml of Raney Nickel and the resulting mixture is hydrogenated at 1 bar until the theoretical amount of hydrogen has been taken up. The mixture is then filtered and the filtrate is concentrated under reduced pressure to give ethyl 3-amino-2-(4-chlorophenyl)propyl-(diethoxymethyl)phosphinate as a viscous oil, 31P=+44.2 and 44.1 ppm (CDCl3).

1. filtrationThe mixture is then filtered
2. concentrationthe filtrate is concentrated under reduced pressure