Butylamine → HCID 15614773, compound

HRID 1084569Notes

Reaction equation

HRID 1084569 reaction equation
Cl[C:2]([CH2:4][N:5]1[C:11]2[CH:12]=[CH:13][CH:14]=[CH:15][C:10]=2[C:9]([C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=2)=[N:8][CH:7]([NH:22][C:23]([O:25][CH2:26][C:27]2[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=2)=[O:24])[C:6]1=[O:33])=[O:3].[CH2:34]([NH2:38])[CH2:35][CH2:36][CH3:37]>>[C:27]1([CH2:26][O:25][C:23](=[O:24])[NH:22][CH:7]2[N:8]=[C:9]([C:16]3[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=3)[C:10]3[CH:15]=[CH:14][CH:13]=[CH:12][C:11]=3[N:5]([CH2:4][C:2](=[O:3])[NH:38][CH2:34][CH2:35][CH2:36][CH3:37])[C:6]2=[O:33])[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=1

Participants

3

Reactant 2

HCID 8007ButylamineHCID 10049958HCID 10049958, compound

Product 1

HCID 15614773HCID 15614773, compound

Procedure

The procedure of Example 134 was carried out using equivalent amounts of 1,3-dihydro-1-chlorocarbonylmethyl-3-(phenylmethyloxycarbonyl)amino-5-phenyl-2H-1,4-benzodiazepin-2-one and n-butylamine. The product was purified by chromatography on silica gel (hexane-ethyl acetate elution). The combined product fractions were evaporated to dryness in vacuo and crystallized to give the title compound which was dried at 65° C.: m.p. 127°-129° C.

Workup

  1. customThe product was purified by chromatography on silica gel (hexane-ethyl acetate elution)
  2. customThe combined product fractions were evaporated to dryness in vacuo
  3. customcrystallized

Sources & evidence

ORD record
ord-98804edbcb814147b10c71697d5f8f37
Source dataset
uspto-grants-1991_04
Patent number
US05004741

Reaction notes

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