HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Bromobenzoyl chloride → L 365031
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Bromobenzoyl chloride | HCID 68515 | — |
| Reactant | 3-Amino-1-methyl-5-phenyl-1H-benzo[E][1,4]diazepin-2(3H)-one | HCID 2729681 | — |
| Product | L 365031 | HCID 196641 | — |
Reaction Steps
The procedure of Example 134 was carried out employing equivalent amounts of 1,3-dihydro-1-methyl-3(RS)-amino-5-phenyl-2H-1,4-benzodiazepin-2-one and 4-bromobenzoyl chloride. The product was purified by chromatography on silica gel (5% (v/v) Et2O in CH2Cl2 elution). The combined product fractions were evaporated to dryness in vacuo and crystallized to give the title compound which was dried at 65° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05004741 |
| Source dataset | uspto-grants-1991_04 |
| ORD ID | ord-f5bb55fffa134791b7e93dc2a86fff18 |
| Source note | uspto-grants-1991_04 |