4-Pentylbenzoyl chloride → HCID 10182876, compound

HRID 1084575Notes

Reaction equation

HRID 1084575 reaction equation
[NH2:1][CH:2]1[N:8]=[C:7]([C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=2[F:15])[C:6]2[CH:16]=[CH:17][CH:18]=[CH:19][C:5]=2[N:4]([CH3:20])[C:3]1=[O:21].[CH2:22]([C:27]1[CH:35]=[CH:34][C:30]([C:31](Cl)=[O:32])=[CH:29][CH:28]=1)[CH2:23][CH2:24][CH2:25][CH3:26]>>[F:15][C:10]1[CH:11]=[CH:12][CH:13]=[CH:14][C:9]=1[C:7]1[C:6]2[CH:16]=[CH:17][CH:18]=[CH:19][C:5]=2[N:4]([CH3:20])[C:3](=[O:21])[CH:2]([NH:1][C:31](=[O:32])[C:30]2[CH:34]=[CH:35][C:27]([CH2:22][CH2:23][CH2:24][CH2:25][CH3:26])=[CH:28][CH:29]=2)[N:8]=1

Participants

3

Reactant 2

HCID 1708124-Pentylbenzoyl chlorideHCID 14423345209985-36-4

Product 1

HCID 10182876HCID 10182876, compound

Procedure

The procedure of Example 134 was carried out using equivalent amounts of 3(R,S)-amino-1,3-dihydro-1-methyl-5-(2-fluorophenyl)-2H-1,4-benzodiazepin-2-one and 4-n-pentylbenzoyl chloride. The product was purified by chromatography on silica gel (5% (v/v) Et2O in CH2Cl2 elution). The combined product fractions were evaporated to dryness in vacuo to give the title compound which was dried at 65° C.

Workup

  1. customThe product was purified by chromatography on silica gel (5% (v/v) Et2O in CH2Cl2 elution)
  2. customThe combined product fractions were evaporated to dryness in vacuo

Sources & evidence

ORD record
ord-272fffcabcdf4123aeff8b28d83bac29
Source dataset
uspto-grants-1991_04
Patent number
US05004741

Reaction notes

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