3-Thenoyl chloride → HCID 14208216, compound

HRID 1084583Notes

Reaction equation

HRID 1084583 reaction equation
[NH2:1][CH:2]1[N:8]=[C:7]([C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=2[F:15])[C:6]2[CH:16]=[CH:17][CH:18]=[CH:19][C:5]=2[N:4]([CH3:20])[C:3]1=[O:21].[S:22]1[CH:26]=[CH:25][C:24]([C:27](Cl)=[O:28])=[CH:23]1>>[F:15][C:10]1[CH:11]=[CH:12][CH:13]=[CH:14][C:9]=1[C:7]1[C:6]2[CH:16]=[CH:17][CH:18]=[CH:19][C:5]=2[N:4]([CH3:20])[C:3](=[O:21])[CH:2]([NH:1][C:27]([C:24]2[CH:25]=[CH:26][S:22][CH:23]=2)=[O:28])[N:8]=1

Participants

3

Reactant 2

HCID 27763773-Thenoyl chlorideHCID 14423345209985-36-4

Product 1

HCID 14208216HCID 14208216, compound

Procedure

The procedure of Example 134 was carried out using equivalent amounts of 3(R,S)-amino-1,3-dihydro-1-methyl-5-(2-fluorophenyl)-2H-1,4-benzodiazepin-2-one and 3-thiophenecarbonyl chloride. The product was purified by chromatography on silica gel (5% (v/v) Et2O in CH2Cl2 elution). The combined product fractions were evaporated to dryness in vacuo to give the title compound which was dried at 65° C.

Workup

  1. customThe product was purified by chromatography on silica gel (5% (v/v) Et2O in CH2Cl2 elution)
  2. customThe combined product fractions were evaporated to dryness in vacuo

Sources & evidence

ORD record
ord-e5b1bb7b85a249e19df96d97c313a344
Source dataset
uspto-grants-1991_04
Patent number
US05004741

Reaction notes

Loading…