3,6-Dichlorophthalic anhydride → Methyl 3-(4,7-dichloro-1,3-dioxo-1,3-dihydro-isoindol-2-yl)-2-(2-methyl-[1,3]dioxolan-2-yl)propionate
Reaction equation
[NH2:1][CH2:2][CH:3]([C:8]1([CH3:13])[O:12][CH2:11][CH2:10][O:9]1)[C:4]([O:6][CH3:7])=[O:5].[Cl:14][C:15]1[CH:25]=[CH:24][C:23]([Cl:26])=[C:17]2[C:18]([O:20][C:21](=O)[C:16]=12)=[O:19]>>[Cl:14][C:15]1[CH:25]=[CH:24][C:23]([Cl:26])=[C:17]2[C:16]=1[C:21](=[O:20])[N:1]([CH2:2][CH:3]([C:8]1([CH3:13])[O:9][CH2:10][CH2:11][O:12]1)[C:4]([O:6][CH3:7])=[O:5])[C:18]2=[O:19]Participants
3
Procedure
Methyl 3-(4,7-dichloro-1,3-dioxo-1,3-dihydro-isoindol-2-yl)-2-(2-methyl-[1,3]dioxolan-2-yl)propionate was prepared (0.23 g, 30%) in the same manner as described in the above example 5 (1) from methyl 3-amino-2-(2-methyl-[1,3]dioxolan-2-yl)propionate (0.40 g, 2.30 mmol) and 3,6-dichlorophthalic anhydride (0.50 g, 2.30 mmol), and the obtained product was identified with the following NMR data.
Sources & evidence
- ORD record
- ord-54daba3da7de46289f7ac27c43312a51
- Source dataset
- uspto-grants-2006_08
- Patent number
- US07094908B2
Reaction notes
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