HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → HCID 131716822, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | 1H-indole-2-carbonyl Chloride | HCID 11816208 | — |
| Reactant | HCID 15167835 | HCID 15167835 | — |
| Solvent | Diethyl Ether | HCID 3283 | — |
| Product | HCID 131716822 | HCID 131716822 | — |
Reaction Steps
Equimolar amounts of 3-(R,S)-amino-1,3-dihydro-1,8-dimethyl-5-phenyl-2H-1,4-benzodiazepin-2-one, indole-2-carbonyl chloride, and triethylamine were mixed at room temperature and stirred 30 minutes. Flash chromatography of the reaction solution on silica gel (7% Et2O in CH2Cl2) provided the title compound as a crystalline solid from Et2O: m.p. 291°-294° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05004741 |
| Source dataset | uspto-grants-1991_04 |
| ORD ID | ord-4648eba4a2f14c0fb65d1534aa988269 |
| Source note | uspto-grants-1991_04 |