Acetone Cyanohydrin → HCID 20062230, compound

Participants

Reaction Steps

A mixture of 2,2-dimethyl-5-(4-chloro-2-nitrobenzoyloxy)-3,6-dihydro-2H-thiopyran-3-one (8.3 g, 24.3 mmol), triethylamine (6.8 ml, 48.7 mmol) and acetone cyanohydrin (0.5 ml) in 35 ml of acetonitrile is stirred at RT for 16 hours. The reaction mixture is concentrated and taken up in ether. The ether extracts are washed with dilute HCl and with brine, dried and evaporated to dryness. The crude product is purified to give 2-2-dimethyl.4.(4.chloro.2.nitrobenzoyl).2H-thiopyran-3,5-(4H,6H)-dione (compound 1, Table A).

Provenance & Evidence