HuagongsheHuagongshe Chemistry Print Report · For research reference only
Diisobutylaluminum hydride → HCID 53701609, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Diisobutylaluminum hydride | HCID 14487 | — |
| Reactant | Trimethyl phosphonoacetate | HCID 80029 | — |
| Reactant | N-benzyloxycarbonylphenylalanine methyl ester | HCID 3082435 | — |
| Product | HCID 53701609 | HCID 53701609 | — |
Reaction Steps
N-Benzyloxycarbonyl phenylalanine methyl ester is reduced with DIBAL to the aldehyde using the procedure of Boger et al., J. Med. Chem. (1985) 28, 1779, which is homologated with the sodio derivative of trimethyl phosphonoacetate using the procedure of Wadsworth and Emmons, Org. Synth. (1965) 45, 44 to give methyl 4-(benzyloxycarbonyl)amino-5-phenyl-2-pentenoate.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05006511 |
| Source dataset | uspto-grants-1991_04 |
| ORD ID | ord-05bfd4e82e6a4f3381cee4991b4f908e |
| Source note | uspto-grants-1991_04 |