Formaldehyde → 11-[4-[2-[(Diethylamino)methyl]-1-piperidinyl]but-2-ynyl]-5,11-dihydro-6H-pyrido[2,3-b][1,4]benzodiazepin-6-one

Participants

Role	Name	HCID	Charge
Reactant	Formaldehyde	HCID 712	—
Reactant	N,N-Diethyl-2-piperidinemethanamine	HCID 254287	—
Reactant	5,11-dihydro-11-(2-propynyl)-6H-pyrido[2,3-b][1,4]benzodiazepin-6-one	HCID 14552085	—
Product	11-[4-[2-[(Diethylamino)methyl]-1-piperidinyl]but-2-ynyl]-5,11-dihydro-6H-pyrido[2,3-b][1,4]benzodiazepin-6-one	HCID 14552087	28%

Reaction Steps

Prepared analogously to Example (1b) from 5,11-dihydro-11-(prop-2-ynyl)-6H-pyrido[2,3-b][1,4]benzodiazepin-6-one, paraformaldehyde and 2-[(diethylamino)methyl]piperidine in a yield of 28% of theory. Colourless crystals, m.p. 132°-134° C.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US05006522
Source dataset	uspto-grants-1991_04
ORD ID	ord-abd30d24bc32439e8de700030b57f3b1
Source note	uspto-grants-1991_04