HuagongsheHuagongshe Chemistry Print Report · For research reference only
Formaldehyde → 11-[4-[(Cyclohexyl)methylamino]-but-2-ynyl]-5,11-dihydro-6H-pyrido[2,3-b][1,4]benzodiazepin-6-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Formaldehyde | HCID 712 | — |
| Reactant | Cyclohexanemethylamine | HCID 76688 | — |
| Reactant | 5,11-dihydro-11-(2-propynyl)-6H-pyrido[2,3-b][1,4]benzodiazepin-6-one | HCID 14552085 | — |
| Product | 11-[4-[(Cyclohexyl)methylamino]-but-2-ynyl]-5,11-dihydro-6H-pyrido[2,3-b][1,4]benzodiazepin-6-one | HCID 20062471 | 17% |
Reaction Steps
Prepared analogously to Example (1b) from 5,11-dihydro-11-(prop-2-ynyl)-6H-pyrido[2,3-b][1,4]benzodiazepin-6-one, paraformaldehyde and (cyclohexyl)methylamine in a yield of 17% of theory. Colourless crystals m.p. 133°-134° C. (diethyl ether).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05006522 |
| Source dataset | uspto-grants-1991_04 |
| ORD ID | ord-47ab0f710ea8479eb3f2fe1a6e0f199d |
| Source note | uspto-grants-1991_04 |