HuagongsheHuagongshe Chemistry Print Report · For research reference only
Formaldehyde → 5,11-Dihydro-11-[4-(1-piperidinyl)-but-2-ynyl]-6H-pyrido[2,3-b][1,4]benzodiazepin-6-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Formaldehyde | HCID 712 | — |
| Reactant | Piperidine | HCID 8082 | — |
| Reactant | 5,11-dihydro-11-(2-propynyl)-6H-pyrido[2,3-b][1,4]benzodiazepin-6-one | HCID 14552085 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 5,11-Dihydro-11-[4-(1-piperidinyl)-but-2-ynyl]-6H-pyrido[2,3-b][1,4]benzodiazepin-6-one | HCID 14552090 | 19% |
Reaction Steps
Prepared analogously to Example lb) from 5,11-dihydro-11-(prop-2-ynyl)-6H-pyrido[2,3-b][1,4]benzodiazepin-6-one, paraformaldehyde and piperidine in a yield of 19% of theory. Colourless crystals m.p. 165°-168° C. (ethyl acetate). The hemifumarate melted at 198° C. (ethanol) with decomposition.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05006522 |
| Source dataset | uspto-grants-1991_04 |
| ORD ID | ord-1c16aed08cc44eb7a8679f067d36c5bf |
| Source note | uspto-grants-1991_04 |