HuagongsheHuagongshe Chemistry Print Report · For research reference only
5,10-Dihydro-11H-dibenzo(b,e)(1,4)diazepin-11-one → 5,10-Dihydro-5-[6-(1-piperidinyl)-hexyl]-11H-dibenzo[b,e][1,4]diazepin-11-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 5,10-Dihydro-11H-dibenzo(b,e)(1,4)diazepin-11-one | HCID 201327 | — |
| Reactant | 1-Bromo6-(1-piperidinyl)hexane | HCID 20062484 | — |
| Reactant | Butyllithium | HCID 178418339 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | 5,10-Dihydro-5-[6-(1-piperidinyl)-hexyl]-11H-dibenzo[b,e][1,4]diazepin-11-one | HCID 14552102 | 46% |
Reaction Steps
Prepared analogously to Example 6 from 5,10-dihydro-11H-dibenzo[b,e][1,4]diazepin-11-one, n-butyl-lithium and 1-bromo-6-(1-piperidinyl)-hexane in a yield of 46% of theory. Colourless crystals, m.p. 124°-125° C. (from acetonitrile using activated charcoal).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05006522 |
| Source dataset | uspto-grants-1991_04 |
| ORD ID | ord-d5a4a16994a4462f855dbe62861cad68 |
| Source note | uspto-grants-1991_04 |