反应详情

A mixture of 50 parts of ethyl 4-[[[[2-[[(5-ethyl-2-furanyl)methyl]amino]-3-pyridinyl]amino]thioxomethyl]amino]-1-piperidinecarboxylate, 32.4 parts of mercury(II) oxide and 480 parts of ethanol was stirred for 1 hours at reflux temperature. The reaction mixture was filtered over diatomaceous earth and the filtrate wax evaporated. The residue was stirred in 1,1'-oxybisethane. The crystallized product was filtered off and dried, yielding 38 parts (83.1%) of ethyl 4-[[3-[(5-ethyl-2-furanyl)methyl]-3H-imidazo[4,5-b]pyridin-2-yl]amino]-1-piperidinecaroxylate; mp. 111.1° C. (int. 14). In a similar manner there was also prepared:

1. temperatureat reflux temperature
2. filtrationThe reaction mixture was filtered over diatomaceous earth
3. customthe filtrate wax evaporated
4. stirringThe residue was stirred in 1,1'-oxybisethane
5. filtrationThe crystallized product was filtered off
6. customdried