反应详情

To silica gel (100 g), 15% aqueous sulfuric acid (15.4 g), and dichloromethane (400 ml) was added 2-(2-fluorobenzyl)-3-thiophenecarboxaldehyde dimethylacetal and dichloromethane (25 ml). The mixture was stirred for 2.5 hrs. The reaction mixture was filtered. The filter cake was washed with ethyl acetate and dichloromethane. The filtrate was concentrated and the residue was purified by flash column chromatography (silica gel, 0.5-10% ethyl acetate/hexanes) to afford 24.0 g (23.5%) of 2-(2-fluorobenzyl)-3-thiophenecarboxaldehyde.

1. filtrationThe reaction mixture was filtered
2. washThe filter cake was washed with ethyl acetate and dichloromethane
3. concentrationThe filtrate was concentrated
4. customthe residue was purified by flash column chromatography (silica gel, 0.5-10% ethyl acetate/hexanes)