Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Methanol | HCID 887 | — |
| Reactant | Tetrahydrofuran | HCID 8028 | — |
| Reactant | Lithium | HCID 3028194 | — |
| Reactant | HCID 14519822 | HCID 14519822 | — |
| Solvent | Water | HCID 962 | — |
| Product | HCID 14519823 | HCID 14519823 | — |
Reaction Steps
A total of 12.2 g of lithium alanate are added in portions to a mixture of 23 g of N-nitroso-tert.-butyl-(2-hydroxy-ethyl)amine and 200 ml of anhydrous tetrahydrofuran at 60° C. When the addition has ended, the mixture is heated at 60° C. for a further hour and cooled in an ice bath and the excess lithium alanate is hydrolysed by careful dropwise addition of methanol and then water. The solids are removed by filtration with suction and the filtrate is concentrated. A colourless oil (14 g) remains and is subsequently used without further purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US05006540 |
|---|
| Source dataset | uspto-grants-1991_04 |
|---|
| ORD ID | ord-c136b7148e92436e96f06efab1f784ef |
|---|
| Source note | uspto-grants-1991_04 |
|---|
