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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 10848Generated: October 26, 2026

Phenylmaleic anhydride → Methyl 3-(2,5-dioxo-3-phenyl-2,5-dihydro-pyrrol-1-yl)-2-(2-methyl-[1,3]dioxolan-2-yl)propionate

https://huagongshe.com/reaction/10848

Reaction equation

Participants

RoleNameHCIDCharge
ReactantPhenylmaleic anhydrideHCID 99174—
ReactantMethyl 3-amino-2-(2-methyl-[1,3]dioxolan-2-yl)propionateHCID 21982209—
ProductMethyl 3-(2,5-dioxo-3-phenyl-2,5-dihydro-pyrrol-1-yl)-2-(2-methyl-[1,3]dioxolan-2-yl)propionateHCID 21982263—

Reaction Steps

Methyl 3-(2,5-dioxo-3-phenyl-2,5-dihydro-pyrrol-1-yl)-2-(2-methyl-[1,3]dioxolan-2-yl)propionate was prepared (1.0 g, 56%) in the same manner as described in the above example 5 (1) from methyl 3-amino-2-(2-methyl-[1,3]dioxolan-2-yl)propionate (1.00 g, 5.29 mmol) and phenylmaleic anhydride (1.10 g, 6.34 mmol), and the obtained product was identified with the following NMR data.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07094908B2
Source datasetuspto-grants-2006_08
ORD IDord-1f6ca9e302e948e0bf4ab1d4a60676d4
Source noteuspto-grants-2006_08